This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

Bien qu’on ne puisse réduire la cohérence narrative des actions racontées par le quatrième évangile à une intrigue unique, une intrigue principale articule et unifie toutes les autres: c’est l’intrigue d’action de Jésus qui le montre «posant son âme» dans une souveraine liberté, accomplissant ainsi l’oeuvre que le Père lui a donnée. La trajectoire des autres personnages est subordonnée à cette intrigue centrale, comme le montre l’exemple des disciples; quant aux micro-récits, ils peuvent pour la plupart être lus comme des (...) anticipations ou des figures de l’oeuvre unique accomplie par Jésus à la croix. (shrink)

The aim of this study was to analyze the association between coaches’ experience and their perceptions on the implementation of a long-term athletic development model created in 2016 by the Portuguese Swimming Federation. Eighty-six swimming coaches were assembled in groups according to their experience level: “novice”, “intermediate”, and “experienced”, and they answered a questionnaire with the following items: awareness of the existing model acceptance usefulness for practice, and implementation of this model by their peers. Regardless of experience, ~67% of the (...) coaches were aware of the model. Among those, a large number showed acceptance and confidence in its usefulness for their daily practice. Most coaches showed concerns about the fact that their peers do not respect the model frameworks, declaring the search for their swimmers’ immediate success as the main cause for such behavior. The results also showed an association between experience and knowledge about the model’s existence [χ2 = 10.223, p < 0.01, V = 0.345], and experienced coaches exhibited better knowledge than their intermediate [χ2 = 9.555, p < 0.01, V = 0.393] or novice [χ2 = 5.926, p = 0.02, V = 0.314] counterparts. While there was an association between the coaches’ experience and knowledge about the LTAD model’s existence, this situation does not seem to influence the way coaches accept and understand the usefulness of the model for their daily practice. (shrink)

L’article examine les raisons philosophiques, plutôt que mathématiques ou logiques, pour lesquelles MacColl a pu vouloir développer une logique propositionnelle. Nous trouvons des éléments de réponse dans le refus discret d’endosser une logique des choses, dans l’anti-psychologisme nuancé de MacColl, et dans une subtile épistémologie de la certitude liée à un usage méthodique de la grammaire.

L’article examine les raisons philosophiques, plutôt que mathématiques ou logiques, pour lesquelles MacColl a pu vouloir développer une logique propositionnelle. Nous trouvons des éléments de réponse dans le refus discret d’endosser une logique des choses, dans l’anti-psychologisme nuancé de MacColl, et dans une subtile épistémologie de la certitude liée à un usage méthodique de la grammaire.

It will be argued that Minkowski's implementation of distances is inconsistent. An alternative implementation will be proposed. In the new model the proper time of an object is taken as its fourth coordinate. Distances will be measured according to a four dimensional Euclidean metric. In the present approach mass is a constant of motion. A mass can therefore be ascribed to photons and neutrinos. Mechanics and dynamics will be reformulated in close correspondence with classical physics. Of particular interest is the (...) equation of motion for the proper time momentum. In the classical limit it reduces to the classical law of conservation of (kinetic+potential) energy. In the relativistic limit it is similar to the conservation of energy of the theory of relativity. The conservation of proper time momentum allows for an alternative explanation for Compton scattering and pair annihilation. On the basis of the proper time formulation of electrodynamics also an alternative explanation will be offered for the spectra of hydrogenic atoms. The proper time formulation of gravitational dynamics leads to the correct predictions of gravitational time dilation, the deflection of light and the precession of the perihelia of planets. For this no curvature will be needed. That is, spacetime is flat everywhere, even in the presence of sources of gravitation. Some cosmological consequences will be discussed. The present approach gives a new notion to energy, antiparticles and the structure of spacetime. The contents of the present paper will have important implications for the foundations of physics in general. (shrink)

Four years after completing his Ph.D. on “The Psychology of Kant,” one of Peirce’s most famous students, John Dewey, published a compendium of Leibniz’s main theses, his 1888 Leibniz’s New Essays.1 Such a move from critical to pre-critical rationalism seems to echo Peirce’s judgment that to fully understand Kant, a thorough familiarity with Leibniz’s philosophy is an indispensable preliminary (N 2:186, 1899); for Kant himself “was reposing in a firm belief in the metaphysics of Leibnitz as theologized by Wolff when (...) he first read the book of Hume.” (W 1:104, 1863) Peirce himself started his reflection with the study of Kant’s thought. The purpose of the present paper is to demonstrate that his actual implicit.. (shrink)

Le philosophe américain Charles S. Peirce ne trouva, malgré ses efforts, guère d’interlocuteurs en France. On le considéra comme un mathématicien et logicien, un physicien et un psychologue fiable, mais son œuvre philosophique fut systématiquement distordue au gré des controverses franco-françaises. Nous mettons l’accent sur les lectures d’André Lalande et de Louis Couturat qui contribuèrent néanmoins à faire reconnaître en France l’originalité du père du pragmaticisme.Despite his efforts, the American philosopher Charles S. Peirce found hardly any interlocutors in France. He (...) was considered mostly as a mathematician and logician, a physicist and a reliable psychologist, but his philosophical work was systematically distorted in consequence of “Franco-French” disputes. We emphasize here the readings of André Lalande and Louis Couturat who made significant contributions towards the recognition in France of the originality of the founding father of Pragmaticism. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

A new description of gravitational motion will be proposed. It is part of the proper time formulation of physics as presented on the IARD 2000 conference. According to this formulation the proper time of an object is taken as its fourth coordinate. As a consequence, one obtains a circular space–time diagram where distances are measured with the Euclidean metric. The relativistic factor turns out to be of simple goniometric origin. It further follows that the Lagrangian for gravitational dynamics does not (...) require an interpretation in terms of curvature of space–time. The flat space model for gravitational dynamics leads to the correct predictions for the bending of light, the perihelion shift of Mercury and gravitational red-shift. The new theory is free of singularities. More important, the new formulation of gravitational dynamics restores the validity of the principle of addition of potentials. One therefore can find solutions for static gravitational configurations for which it is difficult to find the solution of the corresponding Einstein equations. The method will be illustrated by means of the orbital precession for non-spherical stellar mass distributions. In case of the bipole mass distribution the agreement with the predictions of the general theory of relativity is very striking. Nevertheless, the new model is far more simple. (shrink)

ABSTRACT : Alfred Fouillee's doctrine of ideas-forces approximates historically and intellectually William James’s theory of will. But Fouillee's criticism of pragmatism also has connections with Pierce's emphasis on the real and the analysis of concepts, and shows an influence of tychism approaching mysticism. -/- .

Introduction - From the Illiad to the Studies on Hysteria: A chronology of the discovery of the unconscious mind - Freud's theories of the unconscious mind - Jung's collective unconscious - Lacan's linguistic paradigm.